A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance

• DOI: 10.1128/aac.36.5.1005
• Publication Date: 2012-06-28T00:05:50Z
• Authors: M P Nikolich; N B Shoemaker; A A Salyers
• Keywords: Bacteroidaceae

The ribosome protection type of tetracycline resistance (Tcr) has been found in a variety bacterial species, but the only two classes described previously, Tet(M) and Tet(O), shared high degree amino acid sequence identity (greater than 75%). Thus, it appeared that this emerged recently evolution spread among different species bacteria by horizontal transmission. We obtained DNA Tcr gene from Bacteroides, genus gram-negative, obligately anaerobic is phylogenetically distant diverse which tet(M) tet(O) have found. Bacteroides defines new class genes, Tet(Q), deduced was 40% identical to or Tet(O). Like tet(O), tet(Q) appears transmission, within group.