In vitro activities of 12 orally administered antimicrobial agents against four species of bacterial respiratory pathogens from U.S. Medical Centers in 1992 and 1993

• DOI: 10.1128/aac.38.10.2419
• Publication Date: 2012-06-28T00:05:50Z
• Authors: A L Barry; M A Pfaller; P C Fuchs; R R Packer
• Keywords: Cefaclor; Broth microdilution; Cefixime; Cefuroxime

Clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae, pyogenes, and Moraxella catarrhalis were gathered from 19 different clinical laboratories throughout the continental United States. The in vitro activities 12 orally administered antimicrobial agents compared by broth microdilution tests with 3,151 bacterial isolates. Among 890 H. influenzae isolates, 30% capable producing beta-lactamase enzymes (12 to 41% medical centers). Most 619 beta-lactamase-negative strains susceptible ampicillicin (MIC, < or = 1.0 micrograms/ml): 5 intermediate susceptibility 2.0 micrograms/ml) 1 strain was ampilicillin resistant 4.0 micrograms/ml). Ninety-two percent 698 M. positive. Of 799 S. pneumoniae 15% penicillin 7% penicillin. prevalence penicillin-susceptible pneumococci institutions ranged 63 95%. Only 1% 764 pyogenes macrolides, but 5% macrolide resistant. 71% 58 penicillin-resistant erythromycin susceptible, whereas 97% 622 susceptible. Penicillin-resistant also relatively cephalosporins amoxicillin. Penicillin-susceptible amoxicillin-clavulanic acid (MIC for 90% tested [MIC90], 0.12/0.06 microgram/ml), cefixime (MIC90, 0.25 cefuroxime axetil 0.5 cefprozil micrograms/ml), cefaclor loracarbef microgram/ml). other species remained study drugs than