Roxithromycin Inhibits Cytokine Production by and Neutrophil Attachment to Human Bronchial Epithelial Cells In Vitro

• DOI: 10.1128/aac.42.6.1499
• Publication Date: 2018-10-09T00:32:51Z
• Authors: Shin Kawasaki; Hajime Takizawa; Takayuki Ohtoshi; Naonobu Takeuchi; Tadashi Kohyama; Hidenori Nakamura; Tsuyoshi Kasama; Kazuo Kobayashi; Kazuhiko Nakahara; Yutaka Morita; Kazuhiko Yamamoto
• Keywords: Roxithromycin; Interleukin 8

We evaluated the effect of roxithromycin on cytokine production and neutrophil attachment to human airway epithelial cells. Roxithromycin suppressed interleukin 8 (IL-8), IL-6, granulocyte-macrophage colony-stimulating factor. It inhibited adhesion modulates local recruitment activation inflammatory cells, which may have relevance its efficacy in diseases.