Antibiotic Resistance Conferred by a Conjugative Plasmid and a Class I Integron in Vibrio cholerae O1 El Tor Strains Isolated in Albania and Italy

• DOI: 10.1128/aac.43.3.693
• Publication Date: 2018-10-09T00:34:19Z
• Authors: Vincenzo Falbo; Alessandra Carattoli; Fabio Tosini; Cristina Pezzella; Anna Maria Dionisi; Ida Luzzi
• Keywords: Spectinomycin; El Tor; Gene cassette

ABSTRACT Multidrug-resistant Vibrio cholerae O1 El Tor strains isolated during the 1994 outbreak of cholera in Albania and Italy were characterized for molecular basis antibiotic resistance. All found to be resistant tetracycline, streptomycin, spectinomycin, trimethoprim, sulfathiazole, vibriostatic compound O/129 (2,4-diamino-6,7-diisopropylteridine). Resistance genes self-transferable by a conjugative plasmid about 60 MDa, with exception spectinomycin resistance, which was conferred aadA1 gene cassette located bacterial chromosome within class 1 integron. The resistance trimethoprim dfrA1 gene, present on plasmid. Although is known borne an integron cassette, 1, 2, or 3 intI not detected as part DNA from studied.