Synergistic Effect of Clindamycin and Atovaquone in Acute Murine Toxoplasmosis

• DOI: 10.1128/aac.43.9.2240
• Publication Date: 2018-10-09T00:35:31Z
• Authors: Olgica Djurković...; Tatjana Nikolić; Florence Robert-G...; Branko Bobić; Aleksandra Nikolić
• Keywords: Atovaquone; Toxoplasmosis

ABSTRACT The effect of clindamycin (CLI) combined with autovaquone (ATO) was examined in a murine model acute toxoplasmosis. Swiss Webster mice intraperitoneally infected 10 2 or 4 tachyzoites the RH strain Toxoplasma gondii were perorally treated either drug alone (for ATO, 5, 25, 50, 100 mg/kg body weight/day; for CLI, 400 mg/kg/day) both ATO plus respectively, 5 25 50 starting day 1 14 days. Survival monitored during 7 weeks. Residual infection assessed by bioassay representative 4-week survivors and parasite DNA detection PCR 7-week survivors. An treatment shown all groups compared to untreated control ( P = 0.0000). Among parasites, CLI at any dose combination protected significantly more animals than 0.0000), but alone, given its good effect, drugs no effective > 0.05). For lowest highest doses (5 were, similarly, 0.035 0.000, respectively) not However, mg/kg/day 20, 33, 78% mice, virtually survivals among those < 0.0005), thus demonstrating significant synergistic against T. . Furthermore, be critical effect. Moreover, absence residual some shows potential this eliminate parasite.