Fluconazole plus Cyclosporine: a Fungicidal Combination Effective against Experimental Endocarditis Due to Candida albicans

• DOI: 10.1128/aac.44.11.2932-2938.2000
• Publication Date: 2002-07-27T09:56:57Z
• Authors: O. Marchetti; J. M. Entenza; D. Sanglard; J. Bille; M. P. Glauser; P. Moreillon
• Keywords: Echinocandins

Recent observations demonstrated that fluconazole plus cyclosporine (Cy) synergistically killed Candida albicans in vitro. This combination was tested rats with C. experimental endocarditis. The MICs of and Cy for the test organism were 0.25 >10 mg/liter, respectively. Rats treated 5 days either Cy, amphotericin B, fluconazole, or fluconazole-Cy. Although used at high doses, peak concentrations serum (up to 4.5 mg/liter) compatible high-dose therapy humans. On other hand, greater than recommended therapeutic levels. Untreated massive pseudohyphal growth both vegetations kidneys. However, only kidneys displayed concomitant polymorphonuclear infiltration. results reflected this dissociation. In vegetations, fungicidal fluconazole-Cy significantly decreased fungal densities compared all groups, including B (P < 0.0001). kidneys, regimens except regimen effective, but remained superior alone sterilizing organs While mechanism responsible interaction is hypothetical, observation opens new perspectives combinations between azoles drugs.