In Vitro and In Vivo Interactions between Miltefosine and Other Antileishmanial Drugs

• DOI: 10.1128/aac.50.1.73-79.2006
• Publication Date: 2005-12-23T10:07:51Z
• Authors: Karin Seifert; Simon L. Croft
• Keywords: Miltefosine; Sodium stibogluconate; Paromomycin

The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin, and sitamaquine was assessed in vitro additionally for the first three combinations vivo. In interactions were indifferent combined B (mean sums fractional inhibitory concentrations [mean summation operatorFICs] ranging from 1.22 to 1.51 at 50% effective concentration [EC50] level 1.08 1.38 EC90 level), operatorFICs 1.33 1.0 1.02, respectively), paromomycin 0.79 0.93 EC50 0.77 1.35 level). Some synergy observed stibogluconate 0.61 0.75 0.49 0.97 EC90). Different found vivo, where highest potentiation activity achieved (activity enhancement index [AEI] up 11.3). No significant when (AEI 2.38). vivo also combination 7.22).