Structure of Trichamide, a Cyclic Peptide from the Bloom-Forming Cyanobacterium Trichodesmium erythraeum , Predicted from the Genome Sequence

• DOI: 10.1128/aem.00380-06
• Publication Date: 2006-06-02T20:36:26Z
• Authors: Sebastian Sudek; Margo G. Haygood; Diaa T. A. Youssef; Eric W. Schmidt
• Keywords: Gene cluster; Cyclic peptide

ABSTRACT A gene cluster for the biosynthesis of a new small cyclic peptide, dubbed trichamide, was discovered in genome global, bloom-forming marine cyanobacterium Trichodesmium erythraeum ISM101 because striking similarities to previously characterized patellamide cluster. The tri consists precursor peptide containing amino acid sequence mature putative heterocyclization gene, an oxidase, two proteases, and hypothetical genes. Based upon detailed analysis, structure predicted trichamide confirmed by Fourier transform mass spectrometry. Trichamide 11 acids, including cysteine-derived thiazole groups, is cyclized N—C terminal amide bond. As first natural product reported from T. , shows power mining prediction discovery products.