A Stenotrophomonas maltophilia TetR-Like Transcriptional Regulator Involved in Fatty Acid Metabolism Is Controlled by Quorum Sensing Signals

• DOI: 10.1128/aem.00635-23
• Publication Date: 2023-06-05T14:06:13Z
• Authors: Xavier Coves; Marc Bravo; Pol Huedo; Òscar Conchillo-Solé; Andromeda-Celeste...; Anna Esteve-Codina; Marc Dabad; Marta Gut; Xavier Daura; Daniel Yero; Isidre Gibert
• Keywords: Stenotrophomonas; Quorum sensing; N-acyl homoserine lactones; Virulence; TetR-like regulator; Fatty acid metabolism; Stenotrophomonas maltophilia; Biofilms; Fatty Acids; Quorum Sensing; Genetics and Molecular Biology; DSF; Acyl-Butyrolactones

The quorum sensing system in Stenotrophomonas maltophilia , in addition to coordinating the bacterial population, controls virulence-associated phenotypes, such as biofilm formation, motility, protease production, and antibiotic resistance mechanisms. Biofilm formation is frequently associated with the persistence and chronic nature of nosocomial infections.