Transcription Factor NsdD Regulates the Expression of Genes Involved in Plant Biomass-Degrading Enzymes, Conidiation, and Pigment Biosynthesis in Penicillium oxalicum

2. Zero hunger 0303 health sciences Gene Expression Profiling Penicillium Pigments, Biological Spores, Fungal Gene Expression Regulation, Enzymologic Fungal Proteins 03 medical and health sciences Biodegradation, Environmental Cellulase Gene Expression Regulation, Fungal Glucan 1,4-alpha-Glucosidase alpha-Amylases Cellulose Polyketide Synthases Transcription Factors
DOI: 10.1128/aem.01039-18 Publication Date: 2018-07-06T10:07:29Z
ABSTRACT
Most filamentous fungi produce a vast number of extracellular enzymes that are used commercially for biorefineries of plant biomass to produce biofuels and value-added chemicals, which might promote the transition to a more environmentally friendly economy. The expression of these extracellular enzyme genes is tightly controlled at the transcriptional level, which limits their yields. Hitherto our understanding of the regulation of expression of plant biomass-degrading enzyme genes in filamentous fungi has been rather limited. In the present study, regulatory roles of a key regulator, PoxNsdD, were further explored in the soil fungus Penicillium oxalicum , contributing to the understanding of gene regulation in filamentous fungi and revealing the biotechnological potential of P . oxalicum via genetic engineering.
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