Fucosylated Human Milk Oligosaccharide Foraging within the Species Bifidobacterium pseudocatenulatum Is Driven by Glycosyl Hydrolase Content and Specificity

• DOI: 10.1128/aem.01707-21
• Publication Date: 2021-11-10T19:35:10Z
• Authors: Guy Shani; Jennifer L. Hoefl...; Britta E. Heiss; Chad F. Masarweh; Jules A. Larke; Nick M. Jensen; Saumya Wickramasi...; Jasmine C. Davis; Elisha Goonatilleke; Amr El-Hawiet; Linh Nguyen; John S. Klassen; Carolyn M. Slupsky; Carlito B. Lebrilla; David A. Mills
• Keywords: 0301 basic medicine; 570; Hydrolases; Breastfeeding; substrate-binding protein; 610; Oligosaccharides; Microbiology; 03 medical and health sciences; fucosylated HMO; Clinical Research; Lactation and Breast Milk; Humans; Nutrition; Pediatric; Bifidobacterium pseudocatenulatum; alpha-L-Fucosidase; 2. Zero hunger; fucosidases; Milk, Human; Prevention; strain specificity; Infant; α-fucosidase; Biological Sciences; glycan metabolism; Medical microbiology; alpha-fucosidase; Milk; milk oligosaccharides; Female; Biochemistry and Cell Biology; Bifidobacterium; Digestive Diseases; Human

Often isolated from the human gut, microbes from the bacterial family Bifidobacteriaceae commonly possess genes enabling carbohydrate utilization. Isolates from breastfed infants often grow on and possess genes for the catabolism of human milk oligosaccharides (HMOs), glycans found in human breast milk.