Inactivation of Bacterial Pathogens following Exposure to Light from a 405-Nanometer Light-Emitting Diode Array
0301 basic medicine
570
Cross Infection
0303 health sciences
Microbial Viability
Electrical engineering. Electronics Nuclear engineering
Light
610
Gram-Positive Bacteria
Microbiology
3. Good health
Disinfection
03 medical and health sciences
Gram-Negative Bacteria
DOI:
10.1128/aem.01892-08
Publication Date:
2009-02-07T09:02:15Z
AUTHORS (4)
ABSTRACT
This study demonstrates the susceptibility of a variety medically important bacteria to inactivation by 405-nm light from an array light-emitting diodes (LEDs), without application exogenous photosensitizer molecules. Selected bacterial pathogens, all commonly associated with hospital-acquired infections, were exposed LED array, and results show that both gram-positive gram-negative species successfully inactivated, general trend showing be more susceptible than bacteria. Detailed investigation bactericidal effect blue-light treatment on Staphylococcus aureus suspensions, for range different population densities, demonstrated illumination can cause complete at high densities: levels corresponding 9-log(10) reduction achieved. The results, which wide including methicillin-resistant aureus, demonstrate that, further development, narrow-spectrum visible-light source has potential provide novel decontamination method applications.
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