Inactivation of Bacterial Pathogens following Exposure to Light from a 405-Nanometer Light-Emitting Diode Array
0301 basic medicine
570
Cross Infection
Microbial Viability
Electrical engineering. Electronics Nuclear engineering
Light
610
Gram-Positive Bacteria
Microbiology
3. Good health
Disinfection
03 medical and health sciences
Gram-Negative Bacteria
DOI:
10.1128/aem.01892-08
Publication Date:
2009-02-07T09:02:15Z
AUTHORS (4)
ABSTRACT
ABSTRACT
This study demonstrates the susceptibility of a variety of medically important bacteria to inactivation by 405-nm light from an array of light-emitting diodes (LEDs), without the application of exogenous photosensitizer molecules. Selected bacterial pathogens, all commonly associated with hospital-acquired infections, were exposed to the 405-nm LED array, and the results show that both gram-positive and gram-negative species were successfully inactivated, with the general trend showing gram-positive species to be more susceptible than gram-negative bacteria. Detailed investigation of the bactericidal effect of the blue-light treatment on
Staphylococcus aureus
suspensions, for a range of different population densities, demonstrated that 405-nm LED array illumination can cause complete inactivation at high population densities: inactivation levels corresponding to a 9-log
10
reduction were achieved. The results, which show the inactivation of a wide range of medically important bacteria including methicillin-resistant
Staphylococcus aureus
, demonstrate that, with further development, narrow-spectrum 405-nm visible-light illumination from an LED source has the potential to provide a novel decontamination method with a wide range of potential applications.
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