Inactivation of Bacterial Pathogens following Exposure to Light from a 405-Nanometer Light-Emitting Diode Array

0301 basic medicine 570 Cross Infection 0303 health sciences Microbial Viability Electrical engineering. Electronics Nuclear engineering Light 610 Gram-Positive Bacteria Microbiology 3. Good health Disinfection 03 medical and health sciences Gram-Negative Bacteria
DOI: 10.1128/aem.01892-08 Publication Date: 2009-02-07T09:02:15Z
ABSTRACT
This study demonstrates the susceptibility of a variety medically important bacteria to inactivation by 405-nm light from an array light-emitting diodes (LEDs), without application exogenous photosensitizer molecules. Selected bacterial pathogens, all commonly associated with hospital-acquired infections, were exposed LED array, and results show that both gram-positive gram-negative species successfully inactivated, general trend showing be more susceptible than bacteria. Detailed investigation bactericidal effect blue-light treatment on Staphylococcus aureus suspensions, for range different population densities, demonstrated illumination can cause complete at high densities: levels corresponding 9-log(10) reduction achieved. The results, which wide including methicillin-resistant aureus, demonstrate that, further development, narrow-spectrum visible-light source has potential provide novel decontamination method applications.
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