Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis
Gene cluster
Heterologous expression
Heterologous
Cloning (programming)
Streptomycetaceae
Peptide Biosynthesis
DOI:
10.1128/aem.01978-13
Publication Date:
2013-08-31T04:32:12Z
AUTHORS (3)
ABSTRACT
Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed gene (the tvaA gene) encoding the thioviridamide precursor peptide. The biosynthesis cluster was identified by heterologous production of in lividans.
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