Association of Bartonella Species with Wild and Synanthropic Rodents in Different Brazilian Biomes

• DOI: 10.1128/aem.02447-16
• Publication Date: 2016-10-08T02:58:21Z
• Authors: Luiz Ricardo Gonç...; Alexsandra Rodrig...; André Luiz Rodrig...; Natalia Serra Mendes; Otávio Luiz Fidel...; Jyan Lucas Beneve...; Heitor Miraglia H...; Paulo Sérgio D'An...; Elba Regina Sampa...; Rosangela Zacaria...; Marcos Rogério André
• Keywords: Bartonella; Arvicolinae

ABSTRACT Bartonella spp. comprise an ecologically successful group of microorganisms that infect erythrocytes and have adapted to different hosts, which include a wide range mammals, besides humans. Rodents are reservoirs about two-thirds described date; some them been implicated as causative agents human diseases. In our study, we performed molecular phylogenetic analyses infecting wild rodents from five Brazilian biomes. order characterize the genetic diversity spp., robust analysis based on three target genes, followed by sequencing, Bayesian inference, maximum likelihood analysis. were detected in 25.6% (117/457) rodent spleen samples analyzed, this occurrence varied among The gltA sequences showed presence 15 haplotypes. Analysis relationship inference species Brazil was closely related A other cricetid North America, probably constituting only one species. Last, genogroup identified present study formed monophyletic included seven distributed distinct conclusion, bacteria is much more frequent widespread than previously recognized. IMPORTANCE reported sites Brazil. identification understanding distribution important may allow authorities recognize potential regions with risk transmission these pathogens domestic animals addition, accessed gaps biology Brazil, such its low host specificity, high diversity, trapped America. Considering newly discovered great ecological plasticity bacteria, new studies aim revealing biological aspects unknown until now needed must be around world. context, impact associated health should assessed future studies.