Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli

• DOI: 10.1128/iai.00460-19
• Publication Date: 2019-08-16T10:31:01Z
• Authors: Milton Maciel; David Bauer; Robin L. Baudier; Jacob Bitoun; John D. Clements; Steven T. Poole; Mark A. Smith; Robert W. Kaminski; Stephen J. Savarino; Elizabeth B. Norton
• Keywords: Antigens, Bacterial; Mice, Inbred BALB C; 0303 health sciences; Escherichia coli Vaccines; Bacterial Toxins; Antibodies, Bacterial; 3. Good health; Enterotoxins; Feces; Mice; 03 medical and health sciences; Adjuvants, Immunologic; Vaccines, Subunit; Animals; Enterotoxigenic Escherichia coli; Female; Escherichia coli Infections

Enterotoxigenic Escherichia coli (ETEC) is a major cause of infectious diarrhea in children, travelers, and deployed military personnel. As such, development of a vaccine would be advantageous for public health. One strategy is to use subunits of colonization factors combined with antigen/adjuvant toxoids as an ETEC vaccine.