Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages

• DOI: 10.1128/iai.00532-18
• Publication Date: 2018-07-26T13:55:22Z
• Authors: Tatiana M. Clemente; Minal Mulye; Anna V. Justis; Srinivas Nallandh...; Tuan M. Tran; Stacey D. Gilk
• Keywords: Innate immunity; 0301 basic medicine; Macrophage; Macrophages; Chemokine CXCL2; Interleukin-17; Type 4 secretion; 3. Good health; Mice, Inbred C57BL; Type IV Secretion Systems; IL-17; 03 medical and health sciences; Bacterial Proteins; Coxiella burnetii; Host-Pathogen Interactions; Animals; Humans; Q Fever; Interleukin-1; Signal Transduction

Coxiella burnetiiis an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires theCoxiellatype IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole membrane into the host cytoplasm, where they manipulate a variety of cell processes.