The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen
Coagulase
0301 basic medicine
570
Antigens, Bacterial
Staphylococcus aureus
T-Lymphocytes
Staphylococcal Vaccines
Staphylococcal Infections
Survival Analysis
3. Good health
Mice, Inbred C57BL
Disease Models, Animal
03 medical and health sciences
616
Microbial Immunity and Vaccines
Animals
Humans
Cells, Cultured
DOI:
10.1128/iai.00549-17
Publication Date:
2017-09-26T00:30:33Z
AUTHORS (6)
ABSTRACT
ABSTRACT Staphylococcus aureus has become increasingly resistant to antibiotics, and vaccines offer a potential solution this epidemic of antimicrobial resistance. Targeting specific T cell subsets is now considered crucial for next-generation anti- S. vaccines; however, there paucity information regarding antigens . This study highlights the importance wall-anchored proteins as human CD4 + activators capable driving antigen-specific Th1 Th17 activation. Clumping factor A (ClfA), which contains N1, N2, N3 binding domains, was found be potent activator. We further investigated subdomains ClfA were involved in activation that full-length N123 N23 activators. Interestingly, N1 subdomain exclusively activating cells. Furthermore, when these used model vaccine, offered Th1- Th17-mediated systemic protection mice upon intraperitoneal challenge. Overall, required maximal both locally systemically.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (36)
CITATIONS (18)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....