Butyrate Differentiates Permissiveness to Clostridioides difficile Infection and Influences Growth of Diverse C. difficile Isolates

• DOI: 10.1128/iai.00570-22
• Publication Date: 2023-01-24T14:00:43Z
• Authors: Daniel A. Pensinger; Andrea T. Fisher; Horia A. Dobrila; William Van Treuren; Jackson O. Gardner; Steven K. Higginb...; Matthew M. Carter; Benjamin Schumann; Carolyn R. Bertozzi; Victoria Anikst; Cody Martin; Elizabeth V. Robi...; Jo May Chow; Rachael H. Buck; Lucy S. Tompkins; Justin L. Sonnenburg; Andrew J. Hryckowian
• Keywords: Clostridioides; Permissiveness; C difficile

Clostridioides difficile is a leading cause of infectious diarrhea in humans, and it imposes tremendous burden on the health care system. Current treatments for C. infection (CDI) include antibiotics fecal microbiota transplant, which contribute to recurrent CDIs face major regulatory hurdles, respectively.