Intestinal Lamina Propria CD4 + T Cells Promote Bactericidal Activity of Macrophages via Galectin-9 and Tim-3 Interaction during Salmonella enterica Serovar Typhimurium Infection

• DOI: 10.1128/iai.00769-17
• Publication Date: 2018-05-28T10:13:55Z
• Authors: Xin Yu; Hongru Zhang; Linyan Yu; Meifang Liu; Zengyan Zuo; Qiuju Han; Jian Zhang; Zhigang Tian; Cai Zhang
• Keywords: CD4-Positive T-Lymphocytes; Male; Salmonella typhimurium; 0303 health sciences; Microbial Viability; Mucous Membrane; Galectins; Macrophages; Immunity, Innate; 3. Good health; Mice, Inbred C57BL; Disease Models, Animal; 03 medical and health sciences; Salmonella Infections; Animals; Protein Interaction Maps; Intestinal Mucosa; Hepatitis A Virus Cellular Receptor 2; Immunity, Mucosal; Protein Binding

The intestinal immune system is crucial for protection from pathogenic infection and maintenance of mucosal homeostasis. We studied the intestinal immune microenvironment in a Salmonella enterica serovar Typhimurium intestinal infection mouse model.