Differential Liver Protein Expression during Schistosomiasis

• DOI: 10.1128/iai.01048-06
• Publication Date: 2006-11-14T02:33:56Z
• Authors: Marina Harvie; Thomas William Jo...; Anne Camille La F...
• Keywords: Proteome

ABSTRACT The arrival of eggs in the liver during Schistosoma mansoni infection initiates a protective granulomatous response; however, as progresses, this response results chronic fibrosis. To better understand impact schistosomiasis on function, we used proteomic approach to identify proteins whose expression was significantly altered schistosome-infected mice 8 weeks postinfection. Identification differentially expressed by mass fingerprinting revealed that schistosome markedly reduced abundance associated with several normal functions (i.e., citric acid cycle, fatty and urea cycle), while stress responses, acute phase reactants, structural components were all more abundant. patterns immunity-related (peroxiredoxin 1, arginase galectin 1) suggested different protein forms are infection. These findings indicate has significant specific and, moreover, alterations isoforms upregulation unique may be valuable new markers disease.