Synergistic Interaction between Candida albicans and Commensal Oral Streptococci in a Novel In Vitro Mucosal Model

• DOI: 10.1128/iai.05896-11
• Publication Date: 2011-11-22T07:00:38Z
• Authors: Patricia I. Diaz; Zhihong Xie; Takanori Sobue; Angela Thompson; Basak Biyikoglu; Austin Ricker; Laertis Ikonomou; Anna Dongari-Bagt...
• Keywords: Commensalism

ABSTRACT Candida albicans is a commensal colonizer of the gastrointestinal tract humans, where it coexists with highly diverse bacterial communities. It not clear whether this interaction limits or promotes potential C. to become an opportunistic pathogen. Here we investigate between and three species streptococci from viridans group, which are ubiquitous abundant oral bacteria. The ability form biofilms Streptococcus oralis , sanguinis gordonii was investigated using flow cell devices that allow abiotic biofilm formation under salivary flow. In addition, designed novel system allows mucosal conditions mimic environment in esophageal mucosae. observed formed synergistic partnership promoted on surfaces surface mucosa analogue. increased presence could be explained by growth-stimulatory effect since were unaffected their growth planktonic coculture . Conversely, invade organotypic models mucosae Moreover, characterization invasion microorganisms suggested more permissive than mucosa. summary, display implications for pathogenic upper tract.