Increased susceptibility to bacterial infection as a sequela of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

• DOI: 10.1128/iai.12.6.1319-1324.1975
• Publication Date: 2020-01-03T01:47:18Z
• Authors: J E Thigpen; R E Faith; E E McConnell; J A Moore
• Keywords: Pseudorabies; Subclinical infection; Weanling; Tetrachlorodibenzo-p-dioxin

The effects of subclinical levels 2,3,7,8-tetrachloridibenzo-p-dioxin (TCDD) on the response mice to infection with either Salmonella bern or Herpesvirus suis, also known as pseudorabies virus, are reported. TCDD is a contaminant certain commercially useful chemicals, such chlorinated phenols herbicides. It has been shown cause thymic atrophy and suppress cell-mediated immunity in laboratory animals. Sublethal were used: 0.5, 1,5, 10, 20 mug/kg, given through gastric tube once weekly for 4 weeks. A significant decrease weight gain compared control occurred at 20-mug dosage. Dose schedules 1 mug more, followed by salmonella infection, resulted increases mortality decreases time from dealth. However, had no effect pseudorabies-infected mice. most important finding this study that extremely low TCDD, which do not produce clinical pathological change, still have capacity affect host defense.