Role of Adult Worm Antigen-Specific Immunoglobulin E in Acquired Immunity toSchistosoma mansoniInfection in Baboons

• DOI: 10.1128/iai.67.2.636-642.1999
• Publication Date: 2019-12-31T15:32:38Z
• Authors: Mramba Nyindo; Thomas M. Kariuki; Paul W. Mola; Idle O. Farah; Lynne Elson; Ronald E. Blanton; Christopher L. King
• Keywords: Schistosoma; Humoral immunity

ABSTRACT Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined correlates protection baboons ( Papio cynocephalus anubis ), which are natural hosts for Schistosoma mansoni and also develop allergic-type infection. In one experiment, animals were exposed to a single infection (1,000 cercariae) or multiple times (100 cercariae per week 10 weeks) subsequently cured praziquantel prior challenge 1,000 cercariae. Singly multiply infected mounted 59 80% reductions worm burden, respectively P < 0.01). second inoculated S. ova recombinant interleukin 12 (IL-12). This produced 37 39% reduction adult burden after 0.05). Parasite-specific IgG, IgE, IgM, peripheral blood cytokine production evaluated. The only both experiments was levels soluble antigen (SWAP)-specific IgE serum at time and/or 6 weeks later. Baboons repeatedly immunized IL-12 developed two- sixfold-greater SWAP-specific than did controls, this correlated r 2 , −0.40 −0.64; <0.01). Thus, unlike mice, worm-specific is uniquely associated acquired similar association parasite-specific among primates schistosomiasis, along pathology, anatomy, genetic make-up, indicates that provide an excellent permissive experimental model understanding innate schistosomiasis humans.