Cytophilic Immunoglobulin Responses toPlasmodium falciparumGlutamate-Rich Protein Are Correlated with Protection against Clinical Malaria in Dielmo, Senegal

• DOI: 10.1128/iai.68.5.2617-2620.2000
• Publication Date: 2002-07-27T10:01:19Z
• Authors: Claude Oeuvray; Michael Theisen; Christophe Rogier; Jean-Francois Trape; Søren Jepsen; Pierre Druilhe
• Keywords: Adult; Adolescent; Plasmodium falciparum; Age Factors; Protozoan Proteins; Antibodies, Protozoan; Infant; Antigens, Protozoan; Senegal; 3. Good health; Immunoglobulin Isotypes; 03 medical and health sciences; 0302 clinical medicine; Child, Preschool; Immunoglobulin G; Animals; Humans; Malaria, Falciparum; Child

ABSTRACTThe goal of this study was to analyze antibody responses toPlasmodium falciparumglutamate-rich protein (GLURP) using clinical data and plasma samples obtained from villagers of Dielmo, Senegal. This molecule was chosen because it is targeted by human antibodies which induce parasite growth inhibition in antibody-dependent cellular inhibition (ADCI) assays. The results showed a strong correlation between protection against malaria attacks and levels of immunoglobulin G2 (IgG2) and IgG3 against GLURP94–489(R0) and IgG3 against GLURP705–1178(R2) when corrected for the confounding effect of age-related exposure to malaria. Thus, GLURP may play a role in the induction of protective immunity againstP. falciparummalaria.