Binding and Activation of Human Plasminogen by Mycobacterium tuberculosis

• DOI: 10.1128/iai.68.7.4327-4330.2000
• Publication Date: 2002-07-27T10:03:59Z
• Authors: Verónica Monroy; Angelica Amador; Blanca Ruiz; Patricia Espinoza...; Wendy Xolalpa; Raul Mancilla; Clara Espitia
• Keywords: Serpin

ABSTRACT The first evidence of the interaction Mycobacterium tuberculosis with plasminogen system is herein reported. By FACScan analysis and affinity blotting, lysine-dependent binding to M. was demonstrated. molecules were 30-, 60-, 66-kDa proteins present in cell wall soluble protein extracts. activation plasminogen, which occurred only presence fibrin not inhibited by host serpin, α 2 -antiplasmin, also