Analysis of Genes Expressed at the Infective Larval Stage Validates Utility of Litomosoides sigmodontis as a Murine Model for Filarial Vaccine Development

• DOI: 10.1128/iai.68.9.5454-5458.2000
• Publication Date: 2002-07-27T10:01:19Z
• Authors: Judith E. Allen; Jennifer Daub; David Guiliano; Amanda McDonnell; Michelle Lizotte-...; David W. Taylor; Mark Blaxter
• Keywords: Expressed Sequence Tags; 0301 basic medicine; Vaccines; Base Sequence; Molecular Sequence Data; 3. Good health; Mice; 03 medical and health sciences; Larva; Animals; Humans; Amino Acid Sequence; Filarioidea

ABSTRACT We used an expressed sequence tag approach to analyze genes by the infective larvae of rodent filarial parasite Litomosoides sigmodontis . One hundred fifty two new were identified, including several proposed as vaccine candidates in studies with human parasites. Our findings have important implications for use L. a model infection.