Naturally Attenuated, Orally Administered Mycobacterium microti as a Tuberculosis Vaccine Is Better than Subcutaneous Mycobacterium bovis BCG

• DOI: 10.1128/iai.70.3.1566-1570.2002
• Publication Date: 2002-07-27T09:56:57Z
• Authors: Yukari C. Manabe; Cherise P. Scott; William R. Bishai
• Keywords: BCG vaccine; Tuberculosis vaccines; Vaccine efficacy; Mycobacterium tuberculosis complex

ABSTRACT Mycobacterium microti is phylogenetically closely related to tuberculosis and a member of that complex organisms. It curved, acid-fast bacillus naturally attenuated with narrow host range for Microtus species only. In this study, we confirm the unique susceptibility voles infection M. relative resistance mice significantly lower organism burden after 8 weeks infection. addition, histopathologic examination lungs reveals lack cellular, granulomatous aggregates characteristically seen in murine past, has been used successfully humans as vaccine against but was associated cutaneous reactions. an attempt circumvent adverse effect, report efficacy aerosol oral vaccination microti. High-dose orogastric resulted statistically significant improvement protection challenge virulent model compared subcutaneous bovis BCG Pasteur vaccination.