Role of sarA in the Pathogenesis of Staphylococcus aureus Musculoskeletal Infection

• DOI: 10.1128/iai.71.1.516-523.2003
• Publication Date: 2002-12-20T23:07:23Z
• Authors: Jon S. Blevins; Mohamed O. Elasri; Scott D. Allmendi...; Karen E. Beenken; Robert A. Skinner; J. Roby Thomas; Mark S. Smeltzer
• Keywords: Pathogenesis

We recently demonstrated that mutation of sarA in clinical isolates Staphylococcus aureus results a phenotype is distinct by comparison to mutants generated the laboratory strain RN6390 (J. S. Blevins, K. E. Beenken, M. O. Elasri, B. Hurlburt, and Smeltzer, Infect. Immun. 70:470-480, 2002). This raises possibility studies demonstrating are attenuated do not accurately reflect role pathogenesis staphylococcal disease. To test this hypothesis, we used murine model musculoskeletal infection assess virulence agr isolate (UAMS-1). By using model, confirmed and/or reduced capacity cause both septic arthritis osteomyelitis.