Association between Protection against Clinical Malaria and Antibodies to Merozoite Surface Antigens in an Area of Hyperendemicity in Myanmar: Complementarity between Responses to Merozoite Surface Protein 3 and the 220-Kilodalton Glutamate-Rich Protein

• DOI: 10.1128/iai.72.1.247-252.2004
• Publication Date: 2003-12-20T02:48:22Z
• Authors: Soe Soe; Michael Theisen; Christian Roussilhon; Khin-Saw- Aye; Pierre Druilhe
• Keywords: Merozoite surface protein

ABSTRACT We performed a longitudinal clinical and parasitological follow-up study in OoDo, village southeast Asia which malaria is hyperendemic, order to assess the association between protection against attacks antibodies three currently evaluated vaccine candidates, merozoite surface protein 1 (MSP1), MSP3, 220-kDa glutamate-rich (GLURP) from Plasmodium falciparum. Our results showed that levels of cytophilic immunoglobulin G3 (IgG3) conserved regions MSP3 GLURP were significantly correlated with P. falciparum malaria. In contrast, noncytophilic IgG4 increased number attacks. Furthermore, we observed complementary effect MSP3- GLURP-specific IgG3 relation protection. individuals did not respond one antigens, strong response other antigen was consistently detected associated protection, suggesting induction both could be important for development protective immunity. The complementarity responses two main targets antibody-dependent cellular inhibition identified date provides first rational basis combining these antigens hybrid formulation.