Serum Levels of the Proinflammatory Cytokines Interleukin-1 Beta (IL-1β), IL-6, IL-8, IL-10, Tumor Necrosis Factor Alpha, and IL-12(p70) in Malian Children with SeverePlasmodium falciparumMalaria and Matched Uncomplicated Malaria or Healthy Controls

• DOI: 10.1128/iai.72.10.5630-5637.2004
• Publication Date: 2004-09-22T23:52:55Z
• Authors: K. E. Lyke; R. Burges; Y. Cissoko; L. Sangare; M. Dao; I. Diarra; A. Kone; R. Harley; C. V. Plowe; O. K. Doumbo; M. B. Sztein
• Keywords: Cerebral Malaria; Proinflammatory cytokine; Pathogenesis

ABSTRACT Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the of these mediators disease pathogenesis, and relationship between host protection injury remains unclear. A total 248 cases severe Plasmodium falciparum malaria among children aged 3 months 14 years residing Bandiagara, Mali, were matched uncomplicated healthy controls. Using modified World Health Organization criteria for defining malaria, we identified 100 cerebral (coma, seizure, obtundation), 17 anemia (hemoglobin, <5 g/dl), 18 combined with anemia, 92 hyperparasitemia (asexual trophozoites, >500,000/mm ). Significantly elevated levels (given as geometric mean concentrations picograms/milliliter) interleukin-6 (IL-6; 485.2 versus 54.1; P = <0.001), IL-10 (1,099.3 14.1; tumor necrosis factor alpha (10.1 7.7; IL-12(p70) (48.9 31.3; 0.004) serum found IL-6 (485.2 141.0; <0.001) 133.9; seen Cerebral was associated significantly (754.5 311.4; (1,405.6 868.6; 0.006) compared without manifestations. Conversely, lower (199.2 487.6; 0.03) (391.1 1,160.9; 0.002) noted hemoglobin at >5 g/dl. Hyperparasitemia (336.6 602.1; 0.002). These results illustrate complex relationships inflammatory P. malaria.