Blood Group, Immunity, and Risk of Infection withVibrio choleraein an Area of Endemicity

• DOI: 10.1128/iai.73.11.7422-7427.2005
• Publication Date: 2005-10-26T07:14:12Z
• Authors: Jason B. Harris; Ashraful I. Khan; Regina C. LaRocque; David J. Dorer; Fahima Chowdhury; Abu S. G. Faruque; David A. Sack; Edward T. Ryan; Firdausi Qadri; Stephen B. Calder...
• Keywords: Cholera; Cholera toxin

ABSTRACT Individuals with blood group O are more susceptible than other individuals to severe cholera, although the mechanism underlying this association is unknown. To assess respective roles of both intrinsic host factors and adaptive immune responses that might influence susceptibility infection Vibrio cholerae , we prospectively followed a cohort household contacts patients cholera in Bangladesh. In study, made novel observation persons were less likely those groups become infected V. O1 (odds ratio [OR], 0.67; 95% confidence interval [CI], 0.53 0.85; P = 0.008). Consistent prior studies, however, develop illness if (OR, 2.3; CI, 0.98 5.59; 0.05). While protected significantly against O1, there was no evidence protection O139. A multivariate analysis demonstrated between from independent age, gender, baseline anti-cholera toxin vibriocidal antibody titers. Based on epidemiologic evidence, propose hypothesis for understanding risk O139 as well developing symptoms once infected.