Arginase I Induction duringLeishmania majorInfection Mediates the Development of Disease

• DOI: 10.1128/iai.73.9.6085-6090.2005
• Publication Date: 2005-08-19T21:35:14Z
• Authors: Virginia Iniesta; Jesualdo Carcelén; Isabel Molano; Pablo M. V. Peixoto; Eloy Redondo; Pilar Parra; Marina Mangas; Isabel Monroy; Maria Luisa Campo; Carlos Gómez Nieto; Inés Corraliza
• Keywords: Inflammation; 0301 basic medicine; Mice, Inbred BALB C; Arginase; Foot; Leishmaniasis, Cutaneous; Th1 Cells; Immunohistochemistry; 3. Good health; Mice, Inbred C57BL; Disease Models, Animal; Mice; 03 medical and health sciences; Th2 Cells; T-Lymphocyte Subsets; Enzyme Induction; Animals; Cytokines; Biomarkers; Leishmania major

ABSTRACT In a previous work, we demonstrated that the induction of arginase I favored replication Leishmania inside macrophages. Now have analyzed differential expression this enzyme in mouse model L. major infection. Ours results show is induced both susceptible and resistant mice during development disease. However, BALB/c-infected tissues, protein parallels time infection, while C57BL/6 mice, upregulated only footpad swelling. The host strains mediated by balance between interleukin-4 (IL-4) IL-12 opposite to nitric oxide synthase II expression. Moreover, inhibition reduces number parasites delays disease outcome BALB/c treatment with l -ornithine increases susceptibility mice. Therefore, could be considered marker leishmaniasis.