Pseudomonas aeruginosa Regulated Intramembrane Proteolysis: Protease MucP Can Overcome Mutations in the AlgO Periplasmic Protease To Restore Alginate Production in Nonmucoid Revertants

• DOI: 10.1128/jb.00215-18
• Publication Date: 2018-05-21T09:32:51Z
• Authors: Camila Delgado; Laura Florez; Ivonne Lollett; Christine Lopez; Shiva Kangeyan; Hansi Kumari; Marios Stylianou; Robert J. Smiddy; Lisa Schneper; Robert T. Sautter; David Smith; George Szatmari; Kalai Mathee
• Keywords: Proteolysis; Neutral protease; Pseudomonadales

Infection by the opportunistic pathogen Pseudomonas aeruginosa is leading cause of morbidity and mortality seen in CF patients. Poor patient prognosis correlates with genotypic phenotypic change bacteria from a typical nonmucoid to mucoid form lung, characterized overproduction alginate. The expression this exopolysaccharide under control an alternate sigma factor, AlgT/U, that regulated posttranslationally series proteases. A better understanding regulatory phenomenon will help development therapies targeting alginate production, ultimately increase length quality life for those suffering CF.