Microbially catalyzed conjugation of GABA and tyramine to bile acids

• DOI: 10.1128/jb.00426-23
• Publication Date: 2024-01-04T14:00:16Z
• Authors: Michael W. Mullowney; Aretha Fiebig; Matthew K. Schniz...; Mary McMillin; Amber R. Rose; Jason Koval; David Rubin; Sushila Dalal; Mitchell L. Sogin; Eugene B. Chang; Ashley M. Sidebottom; Sean Crosson
• Keywords: Tyramine; Pouchitis; Bacteroides thetaiotaomicron; Bacteroides fragilis

Bile acids (BAs) are cholesterol-derived molecules that aid in digestion and nutrient absorption, regulate host metabolic processes, influence physiology of the gut microbiota. Both its microbiome contribute to enzymatic modifications shape chemical diversity BAs gut. Several bacterial species have been reported conjugate standard amino BAs, but it was not known if bacteria other amine classes. Here, we show