Modulation of Horizontally Acquired Genes by the Hha-YdgT Proteins in Salmonella enterica Serovar Typhimurium

• DOI: 10.1128/jb.01206-07
• Publication Date: 2007-11-27T04:40:31Z
• Authors: Aitziber Vivero; Rosa C. Baños; Javier F. Mariscotti; Juan Carlos Oliveros; Francisco García...; Antonio Juárez; Cristina Madrid
• Keywords: Salmonella typhimurium; 0301 basic medicine; Mice, Inbred BALB C; Salmonella Infections, Animal; Gene Transfer, Horizontal; Proteome; Transcription, Genetic; Virulence; Reverse Transcriptase Polymerase Chain Reaction; Gene Expression Regulation, Bacterial; DNA-Binding Proteins; Mice; 03 medical and health sciences; Bacterial Proteins; Animals

ABSTRACT

We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.