Complete Genome Sequence of Burkholderia rhizoxinica , an Endosymbiont of Rhizopus microsporus

• DOI: 10.1128/jb.01318-10
• Publication Date: 2010-12-04T05:44:05Z
• Authors: Gerald Lackner; Nadine Moebius; Laila Partida-Mar...; Christian Hertweck
• Keywords: Nonribosomal peptide

ABSTRACT Burkholderia rhizoxinica is an intracellular symbiont of the phytopathogenic fungus Rhizopus microsporus . The vertically transmitted endosymbiont not only delivers antimitotic macrolide rhizoxin to its host but also essential for vegetative spore formation fungus. To shed light on genetic equipment this model organism, we sequenced whole genome B. HKI 0454, thus providing first genomic insight into mutualist a fungal species. 3.75-Mb consists chromosome and two strain-specific plasmids. primary metabolism appears be specialized uptake metabolites. Besides biosynthesis gene cluster, there are 14 loci coding nonribosomal peptide synthetase (NRPS) assembly lines, which represent novel targets mining cryptic natural products. Furthermore, endosymbionts equipped with repertoire virulence-related factors, can now studied elucidate molecular mechanisms underlying bacterial-fungal interaction.