National Surveillance of Fungemia in Denmark (2004 to 2009)

• DOI: 10.1128/jcm.01811-10
• Publication Date: 2010-10-28T02:25:13Z
• Authors: Maiken Cavling Ar...; Brita Bruun; Jens Jørgen Chris...; Kurt Fuursted; Helle Krogh Johansen; Poul Kjældgaard; Jenny Dahl Knudsen; Lise Kristensen; Jens Møller; Lene Nielsen; Flemming Schønnin...; Bent Røder; Henrik Carl Schøn...; Marianne K. Thomsen; Kjeld Truberg
• Keywords: Fungemia; Candida parapsilosis; Candida glabrata

A 6-year nationwide study of fungemia in Denmark was performed using data from an active surveillance program and laboratory information systems nonparticipating regions. total 2,820 episodes were recorded. The incidence increased 2004 to 2007 (7.7 9.6/100,000) decreased slightly 2008 2009 (8.7 8.6/100,000). highest incidences seen at the extremes age (i.e., 11.3 37.1/100,000 for those <1 70 79 years old, respectively). rate higher males than females (10.1 versus 7.6/100,000, P = 0.003), with largest difference observed patients >50 age. species distribution varied significantly by both gender. Candida accounted 98% pathogens, C. albicans predominant, although proportion (64.4% 53.2%, < 0.0001). glabrata ranked second, (16.5% 25.9%, 0.003). more common adults children males, whereas tropicalis (P 0.020). krusei a rare isolate (4.1%) except one university hospital. Acquired resistance amphotericin echinocandins rare. However, fluconazole (MIC >4 μg/ml) occurred (7/1,183 [0.6%]), dubliniensis (2/65 [3.1%]), parapsilosis (5/83 [6.0%]), (7/104 [6.7%]). Overall, 70.8% isolates fully susceptible, but (79.7% 68.9%, 0.02). confirmed three times other Nordic countries identified marked differences related Decreased susceptibility frequent increasing.