First Detection of TR34 L98H and TR46 Y121F T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States

• DOI: 10.1128/jcm.02478-15
• Publication Date: 2015-10-22T15:02:03Z
• Authors: Nathan P. Wiederhold; Veronica Garcia Gil; Felipe Gutierrez; Jonathan R. Lindner; Mohammad T. Albat...; Dora I. McCarthy; Carmita Sanders; Hongxin Fan; Annette W. Fother...; Deanna A. Sutton
• Keywords: Azole

Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur patients without previous azole exposure have been reported Europe, Asia, the Middle East, Africa, Australia. Here, we report detection of both confirmed A. isolates collected institutions United States. These mutations, other known to cause resistance, MICs are here.