High Prevalence of Hepatitis B Virus Pre-S Mutant in Countries Where It Is Endemic and Its Relationship with Genotype and Chronicity

• DOI: 10.1128/jcm.41.12.5449-5455.2003
• Publication Date: 2003-12-08T23:38:01Z
• Authors: Tran Thien-Tuan Huy; Hiroshi Ushijima; Khin Maung Win; Pairoj Luengrojan...; Pradeep Krishna S...; Zhao-Hua Zhong; Andrei V. Smirnov; Teresa Casanovas ...; Tetsutaro Sata; Kenji Abe
• Keywords: Hepatitis B

ABSTRACT It has been reported that hepatitis B virus (HBV) mutants carrying mutations in the pre-S region can be found infected patients. In this study, we investigated prevalence of HBV variant with mutant different geographic regions, including countries low and high levels endemic infection, analyzed correlation clinical findings. We examined 387 DNA-positive serum samples from individuals among 12 countries, consisting Vietnam, Myanmar, Thailand, China, Korea, Nepal, Japan, Russia, Spain, United States, Bolivia, Ghana. were detected 71 (18.3%) tested. This was most prevalent Vietnam (36%), followed by Nepal (27.3%), Myanmar (23.3%), China (22.4%), Korea (14.3%), Thailand (10.5%), Japan (7.7%), Ghana (4.3%). contrast, no case mutation Bolivia. Among deletion mutations, 15.5% (11 71) occurred pre-S1 46.5% (33 pre-S2 regions. Eight (11.3%) cases had a both addition, point at starting codon observed 19 (26.7%) cases. The detection rate patients hepatocellular carcinoma significantly higher than other ( P < 0.05). Furthermore, these more frequently genotype (25%) C (24.5%) genotypes Our results indicated there regions infection Asia. appeared to correlated genotypes.