Cross-Species Transmission in the Speciation of the Currently Known Murinae-Associated Hantaviruses
Genetic algorithm
DOI:
10.1128/jvi.00021-12
Publication Date:
2012-08-02T00:21:45Z
AUTHORS (11)
ABSTRACT
To gain more insight into the phylogeny of Dabieshan virus (DBSV), carried by Niviventer confucianus and other Murinae-associated hantaviruses, genome sequences novel variants DBSV were recovered from rats trapped in mountainous areas Wenzhou, China. Genetic analyses show that all known genetic DBSV, including ones identified this study, are distinct hantaviruses. geographic clustering high intraspecies diversity. The data suggest is a species genus Hantavirus. Interestingly, shows highest sequence identity to Hantaan (HTNV), with >7% difference N, GPC, L proteins, while N. closely related Rattus norvegicus (the host Seoul [SEOV]) than Apodemus agrarius HTNV Saaremaa [SAAV]). Further hantaviruses (both established tentative species) many them, may have originated switching. estimation evolutionary rates divergence time supports role cross-species transmission evolution detection positive selection suggests drift contribute speciation adaptation has as well.
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