Cross-Species Transmission in the Speciation of the Currently Known Murinae-Associated Hantaviruses
0303 health sciences
Base Sequence
Geography
Genetic Speciation
Sequence Analysis, RNA
Hantavirus Infections
Molecular Sequence Data
Genetic Variation
Sequence Analysis, DNA
Cytochromes b
Hantaan virus
Rats
3. Good health
Rodent Diseases
Viral Proteins
03 medical and health sciences
Animals
RNA, Viral
Murinae
Phylogeny
DOI:
10.1128/jvi.00021-12
Publication Date:
2012-08-02T00:21:45Z
AUTHORS (11)
ABSTRACT
ABSTRACTTo gain more insight into the phylogeny of Dabieshan virus (DBSV), carried byNiviventer confucianusand otherMurinae-associated hantaviruses, genome sequences of novel variants of DBSV were recovered fromNiviventerrats trapped in the mountainous areas of Wenzhou, China. Genetic analyses show that all known genetic variants of DBSV, including the ones identified in this study, are distinct from otherMurinae-associated hantaviruses. DBSV variants show geographic clustering and high intraspecies diversity. The data suggest that DBSV is a distinct species in the genusHantavirus. Interestingly, DBSV shows the highest sequence identity to Hantaan virus (HTNV), with a >7% difference in the sequences of the N, GPC, and L proteins, whileN. confucianusis more closely related toRattus norvegicus(the host of Seoul virus [SEOV]) than toApodemus agrarius(the host of HTNV and Saaremaa virus [SAAV]). Further genetic analyses of all knownMurinae-associated hantaviruses (both established and tentative species) show that many of them, including DBSV, may have originated from host switching. The estimation of evolutionary rates and divergence time supports the role of cross-species transmission in the evolution ofMurinae-associated hantaviruses. The detection of positive selection suggests that genetic drift may contribute to the speciation ofMurinae-associated hantaviruses and that adaptation has a role as well.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (74)
CITATIONS (31)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....