Wide Variation in the Multiplicity of HIV-1 Infection among Injection Drug Users

• DOI: 10.1128/jvi.00077-10
• Publication Date: 2010-04-08T01:10:20Z
• Authors: Katharine J. Bar; Hui Li; Annie Chamberland; Cecile Tremblay; Jean Pierre Routy; Truman Grayson; Chuanxi Sun; Shuyi Wang; Gerald H. Learn; Charity J. Morgan; Joseph E. Schumacher; Barton F. Haynes; Brandon F. Keele; Beatrice H. Hahn; George M. Shaw
• Keywords: Sexual transmission; Multiplicity of infection

Recent studies indicate that sexual transmission of human immunodeficiency virus type 1 (HIV-1) generally results from productive infection by only one virus, a finding attributable to the mucosal barrier. Surprisingly, recent study injection drug users (IDUs) St. Petersburg, Russia, also found most subjects be acutely infected single virus. Here, we show single-genome amplification and sequencing in different IDU cohort 60% were more than including subject who was at least 16 viruses. Multivariant common IDUs heterosexuals (60% versus 19%; odds ratio, 6.14; 95% confidence interval [CI], 1.37 31.27; P = 0.008). These findings highlight diversity HIV-1 risks among cohorts challenges faced vaccines protecting against this mode infection.