A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts

• DOI: 10.1128/jvi.00564-19
• Publication Date: 2019-06-24T14:39:07Z
• Authors: Shoaleh Dehghan; Jason Seto; Elizabeth B. Liu; Ashrafali M. Ismail; Ramana Madupu; Albert Heim; Morris S. Jones; David W. Dyer; James Chodosh; Donald Seto
• Keywords: Zoonosis; Simian; Human pathogen; Bonobo

Genomics analysis of a historically intriguing and predicted emergent human adenovirus (HAdV) pathogen, which caused pneumonia death, provides insight into novel molecular evolution pathway involving "ping-pong" zoonosis anthroponosis. The genome this promiscuous pathogen is embedded with evidence unprecedented multiple, multidirectional, stable, reciprocal cross-species infections hosts from three species (human, chimpanzee, bonobo). This recombinant genome, typed as HAdV-B76, identical to two recently reported simian AdV (SAdV) genomes isolated chimpanzees bonobos. Additionally, the presence critical adenoviral replication element found in HAdV genomes, addition genes that are highly similar counterparts other HAdVs, reinforces its potential pathogen. Reservoirs nonhuman may explain periods apparent absence then reemergence pathogens, well present pathways for genesis those thought be newly emergent. nature HAdV-D76 has implications use SAdVs gene delivery vectors therapy vaccines, selected avoid preexisting potentially fatal host immune responses HAdV.IMPORTANCE An associated fatality 1965, shows remarkable degree identity adenoviruses contain recombination events hosts: human, bonobo. Zoonosis (nonhuman-to-human transmission) anthroponosis (human play significant roles emergence pathogens.