Comparison of Crimean-Congo Hemorrhagic Fever Virus and Aigai Virus in Life Cycle Modeling Systems Reveals a Difference in L Protein Activity

• DOI: 10.1128/jvi.00599-22
• Publication Date: 2022-06-13T13:08:08Z
• Authors: Matthew J. Pickin; Stéphanie Devignot; Friedemann Weber; Martin H. Groschup
• Keywords: Gene Expression Regulation, Viral; 0303 health sciences; Genotype; Virulence; Genome Replication and Regulation of Viral Gene Expression; 3. Good health; Europe; Disease Models, Animal; 03 medical and health sciences; Species Specificity; Africa; Hemorrhagic Fever Virus, Crimean-Congo; Animals; Humans; Hemorrhagic Fever, Crimean

Crimean-Congo hemorrhagic fever virus (CCHFV) is the cause of severe hemorrhagic disease, which is often fatal. Present throughout Africa, Asia, and Southeast Europe, a diverse number of viral genotypes exist.