The Transmembrane Domain of BST-2 Determines Its Sensitivity to Down-Modulation by Human Immunodeficiency Virus Type 1 Vpu

• DOI: 10.1128/jvi.00620-09
• Publication Date: 2009-05-28T00:51:20Z
• Authors: Liwei Rong; Jianyong Zhang; Jennifer Lu; Qinghua Pan; René-Pierre Lorg...; Claudette Aloysius; Fei Guo; Shan-Lu Liu; Mark A. Wainberg; Chen Liang
• Keywords: Tetherin

ABSTRACT Bone marrow stromal cell antigen 2 (BST-2, also known as tetherin) restricts the production of a number enveloped viruses by blocking virus release from surface. This antiviral activity is counteracted such viral factors Vpu human immunodeficiency type 1 (HIV-1). Here, we report that antagonizes BST-2 but not derived African green monkeys. The determinants susceptibility to map transmembrane domain BST-2. In accordance with this, expression containing modified effectively blocks replication wild-type Vpu-expressing HIV-1 in CD4 + T cells. Furthermore, these variants, opposed BST-2, are refractory Vpu-mediated down-regulation result an attenuated interaction Vpu. view work others pointing key role promoting release, our data suggest direct through each two proteins prerequisite for down-modulate