Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains

• DOI: 10.1128/jvi.01014-15
• Publication Date: 2015-04-30T02:12:03Z
• Authors: Soledad Negrotto; Hebe A. Mena; Agustin E. Ure; Carolina Jaquenod...; Mariela Bollati-F...; Elba M. Vermeulen; Mirta Schattner; Ricardo M. Gómez
• Keywords: Junin virus; Arenavirus

ABSTRACT The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized JUNV infection human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to with C#1 strain (attenuated) and even more P (virulent) strain. However, elicited different responses in terms viability, activation, maturation, cytokine expression after both strains.