Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection

• DOI: 10.1128/jvi.01173-18
• Publication Date: 2018-11-09T11:37:30Z
• Authors: Kendra A. Bussey; Sripriya Murthy; Elisa Reimer; Baca Chan; Bastian Hatesuer; Klaus Schughart; Britt Glaunsinger; Heiko Adler; Melanie M. Brinkmann
• Keywords: 0301 basic medicine; herpesviruses; Biomedical and clinical sciences; pattern recognition receptor; Herpesviruses ; Mhv68 ; Toll-like Receptor ; Dendritic Cells ; Murine Gammaherpesvirus 68 ; Pattern Recognition Receptor ; Type I Interferon; Inbred C57BL; Virus Replication; Medical and Health Sciences; Mice; veterinary and food sciences; 2.1 Biological and endogenous factors; 2.2 Factors relating to the physical environment; Cancer; Mice, Knockout; Membrane Glycoproteins; Herpesviridae Infections; Biological Sciences; Virus Latency; 3. Good health; Biological sciences; Infectious Diseases; Medical Microbiology; HIV/AIDS; type I interferon; Female; Infection; Signal Transduction; Knockout; Immunology; 610; Endosomes; 03 medical and health sciences; Rare Diseases; Gammaherpesvirinae; Toll-like receptor; Virology; Animals; dendritic cells; Agricultural; Biomedical and Clinical Sciences; Agricultural and Veterinary Sciences; Inflammatory and immune system; Mesenchymal Stem Cells; Dendritic Cells; Mice, Inbred C57BL; Emerging Infectious Diseases; Toll-Like Receptor 7; Toll-Like Receptor 9; Sexually Transmitted Infections; murine gammaherpesvirus 68; MHV68; Virus Activation

Murine gammaherpesvirus 68 (MHV68) is a small-animal model suitable for study of the human pathogens Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here, we have characterized roles endosomal Toll-like receptor (TLR) escort protein UNC93B, TLR7, -9, -13, cell surface TLR2 in MHV68 detection. We found that alpha interferon (IFN-α) response plasmacytoid dendritic cells (pDC) to was reduced