Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines

• DOI: 10.1128/jvi.01261-07
• Publication Date: 2007-08-30T00:59:47Z
• Authors: Sunil Kannanganat; Bill G. Kapogiannis; Chris Ibegbu; Lakshmi Chennareddi; Paul Goepfert; Harriet L. Robinson; Jeffrey Lennox; Rama Rao Amara
• Keywords: Proinflammatory cytokine; Interleukin 18

Here, we evaluate the cytokine coexpression profiles of human immunodeficiency virus (HIV)-specific CD4 T cells for expression cytokines gamma interferon (IFN-gamma), interleukin-2, and tumor necrosis factor alpha. In controllers, producing three or two (triple producers double producers, respectively) represented >50% total response. contrast, in noncontrollers approximately 75% responding produced only one (single producers), mostly IFN-gamma. Cells were functionally superior to those single showed an inverse correlation (P < 0.001) with viral load. These results demonstrate a strong association between maintenance highly functional control HIV-1.