Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State

• DOI: 10.1128/jvi.01372-19
• Publication Date: 2019-10-01T13:14:31Z
• Authors: Tonya Kueck; Louis-Marie Bloyet; Elena Cassella; Trinity Zang; Fabian Schmidt; Vesna Brusic; Gergely Tekes; Owen Pornillos; Sean P. J. Whelan; Paul D. Bieniasz
• Keywords: Transcription; Vesicular Stomatitis

Interferons are important antiviral cytokines that work by inducing hundreds of host genes whose products inhibit the replication many viruses. While activity interferon has long been known, identities and mechanisms action most interferon-induced proteins remain to be discovered. We identified gene for against vesicular stomatitis virus (VSV), a model genome consists single RNA molecule with negative-sense polarity. found particular protein, TRIM69, functions previously undescribed molecular mechanism. Specifically, TRIM69 interacts inhibits function phosphoprotein (P) component viral transcription machinery, preventing synthesis messenger RNAs.