Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines

• DOI: 10.1128/jvi.01460-06
• Publication Date: 2006-11-13T19:03:38Z
• Authors: Xiao-Song He; Tyson H. Holmes; Caiqiu Zhang; Kutubuddin Mahmood; George W. Kemble; David B. Lewis; Cornelia L. Dekker; Harry B. Greenberg; Ann M. Arvin
• Keywords: Inactivated vaccine; Attenuated vaccine; Cellular immunity

The patterns of cellular immune responses induced by live attenuated influenza vaccine (LAIV) versus those the trivalent inactivated (TIV) have not been studied extensively, especially in children. goals this study were to evaluate effects TIV and LAIV immunization on immunity A virus children adults explore factors associated with variations vaccines among individuals. gamma interferon (IFN-gamma) flow cytometry assay was used measure IFN-gamma-producing (IFN-gamma+) NK T cells peripheral blood mononuclear cell cultures stimulated a strain before after or adults. mean percentages virus-specific IFN-gamma+ CD4 CD8 increased significantly LAIV, but TIV, aged 5 9 years. No increases levels virus-reactive observed given TIV. significant increase 6-month- 4-year-old children; evaluated age group. postvaccination changes (n-fold) highly variable correlated inversely prevaccination percentages, particular that CD56(dim) subset. In conclusion, our findings identify age, type vaccine, reactivity as magnitude vaccines.