A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque

• DOI: 10.1128/jvi.01568-20
• Publication Date: 2020-11-12T14:12:59Z
• Authors: Tiffany Jenkins; Rongzhang Wang; Olivia Harder; Miaoge Xue; Phylip Chen; Jacqueline Corry; Christopher Walker; Michael Teng; Asuncion Mejias; Octavio Ramilo; Stefan Niewiesk; Jianrong Li; Mark E. Peeples
• Keywords: Male; S-Adenosylmethionine; 0303 health sciences; Binding Sites; Vaccination; Respiratory Syncytial Virus Infections; Virus Replication; Macaca mulatta; 3. Good health; Viral Proteins; 03 medical and health sciences; Viral Envelope Proteins; Respiratory Syncytial Virus, Human; Mutation; Respiratory Syncytial Virus Vaccines; Animals; Humans; Female; Sigmodontinae

Globally, respiratory syncytial virus (RSV) is a major cause of death in children under 1 year of age, yet no vaccine is available. We have generated a novel RSV live attenuated vaccine candidate containing mutations in the L and G proteins.